HTR2C and cyclic hematopoiesis: With particular relevance to the anti-addictive properties of CH, there are a number of reported observations of opposing effects between the 5-HT2C and 5-HT2A receptor subtypes, with 5-HT2A receptors facilitating and 5-HT2C receptors suppressing dopamine neurotransmission (Bubar and Cunningham, 2008; De Deurwaerdere and Spampinato, 1999; Filip et al., 2004, 2006; Fletcher et al., 2002; McMahon and Cunningham, 2001; McMahon et al., 2001).