The central role that STAT3 plays in the regenerative mechanisms induced by IL-10 is underscored and may have significant clinical and translational applications that would improve the care of patients who cope with debilitating conditions, including pulmonary and renal fibrosis, intra-abdominal adhesions, some traumatic injuries, burn scars, and scleroderma. This evidence concerns the gene STAT3 and scleroderma.