Although our present study clearly demonstrated that DENV-2 clinical isolate P04/08 caused lethal infection in IFN-α/β/γR KO and IFN-α/β/γR/FcγRIIB KO mice, we did not detect any vascular leakage in DV2P04/08-infected mice (data not shown). The gene discussed is FCGR2B; the disease is infection.