HIV-1 infection is associated with polyclonal B-cell activation, hypergammaglobulinemia, the presence of immature/transitional CD10+ or exhausted CD27 negative B-cells in blood [1, 2], exhaustion of tissue-like memory (CD20(hi)/CD27(−)/CD21(lo)) B-cells [3], loss of total B-cell populations [4, 5], and nonspecific switching from IgM to IgG, IgA and IgE responses. This evidence concerns the gene CD27 and HIV-1 infection.