As it was observed in the results, DNA immunization induces the synthesis of cytokines of Th1 profile which can activate T cells, however, the immunization with the recombinant protein induces a cytokine profile similar to that observed during virus infection, where a marked expression of IL-10 gene and production of IL-1, IL-6, and TNF-α is observed. The gene discussed is IL6; the disease is viral infectious disease.