BSG and cancer: The role of CD147 in cancer migration has been associated with: the regulation of matrix metalloproteinases (MMPs), the essential enzymes for extracellular matrix (ECM) degradation [7, 10]; the rearrangement of cytoskeleton that mediated mesenchymal movement; and the activation of other molecular pathway including uPA, intergrin-FAK-PI3K and TGF-beta [11–13].