To determine the mechanism of WP action in the biology of ID-MA tumor cell phenotypes in this study, we used attenuators of WP signals including WntC59 and XAV939, beta-catenin siRNA, sulindac sulfide as well as stimulators of WP signals including Wnt3A recombinant protein and LWnt3ACM. The gene discussed is CTNNB1; the disease is neoplasm.