The research carried out by Naylor et al., and Colvin, demonstrated that TNF-α has a major function in ovarian cancer development that resembles present study in which there was a significantly increase in levels of TNF-α in ovarian cancer patients as compare to healthy individuals showing a significant positive correlation with MMP-2 (r = 0.325**)[26, 27]. This evidence concerns the gene TNF and ovarian carcinoma.