Graves’ orbitopathy (GO) affects 10% to 25% of patients with Graves’ disease (GD) and is influenced by nonpreventable factors, such as age, sex, and genetic predisposition, and exogenous factors such as cigarette smoking, poorly controlled thyroid dysfunction (both hyperthyroidism and hypothyroidism), and radioiodine (RAI) treatment.[1,2] GO is an inflammation of extraocular muscles and peri-orbital connective tissue mediated by auto-antibodies against common antigens to both thyroid and orbit such as thyroid-stimulating hormone receptor.[3,4]. This evidence concerns the gene TSHR and geroderma osteodysplastica.