LOX downmodulation has been found in SCC and its lack has been shown to induce the extracellular matrix disorganization leading to tumor development.[21] Furthermore, in addition to being potentially involved in tumor development, some of the affected genes that were observed in this case might also play a relevant role in a targeted therapy approach in patients affected by lung cancer, possibly reducing sensitivity to currently registered agents or eventually representing potential targets for drugs that might become available for lung cancer in future. This evidence concerns the gene LOX and neoplasm.