Both ADC and SCC showed lung tumor hotspot mutations reported in the Catalogue of Somatic Mutations in Cancer (COSMIC; http://cancer.sanger.ac.uk/cosmic) database and described in lung cancers: EHHADH (COSM5247826), KRAS (COSM512), OR4K2 (COSM1515038), and TP53 (COSM6549) in ADC; KIAA1324L (COSM396629), NFE2L2 (COSM396629), PEG3 (COSM5284477), POM121L12 (COSM393793), and WAC (COSM5311283) in SCC. Here, KRAS is linked to AIDS dementia complex.