HHV-8, a member of the gamma-herpesvirinae, is the etiologic agent of all clinical-epidemiological forms of Kaposi's sarcoma, namely, classic, endemic, iatrogenic and epidemic or AIDS-KS.[1] Since the impact of HIV epidemic, AIDS-KS has been considered the most severe and treatment-resistant form of KS tumor.[2,3] With despite the undetectable HIV viral load and recovery of CD4 levels following cART, a substantial proportion of persistent KS have been described in AIDS patients.[4–6] Additional factors involved in the development and progression of AIDS-KS need to be further explored. The gene discussed is CD4; the disease is Kaposi's sarcoma.