There is scant information on the distribution of HHV-8 genotype in Brazil.[13,18,21,23,25] Herein, we investigated whether there is an association between HHV-8 variability and development of AIDS-KS by performing a phylogenetic analysis of complete and partial K1 sequences of the HHV-8 genome and profiles of the viral genotype and subgenotype of AIDS individuals without or with KS. The gene discussed is KRT1; the disease is Kaposi's sarcoma.