In AML cells, cytarabine, daunorubicin, all-trans retinoic acid (ATRA) and valproic acid were also found to induce increased calreticulin exposure (ecto-CRT) and release of HSP70 and HSP90, which indicating an induction of immunogenic apoptosis, although the level of CRT exposure/HSP release seems to depend on individual patients characteristics rather than the apoptosis-inducing drug [102]. The gene discussed is CALR; the disease is acute myeloid leukemia.