Also in HT29 colon cancer cells miR-196b-5p transfection led to a decrease of pL-G6-3′UT and pL-196TS reporter activity, albeit to a lesser extent with respect to HCT116 cells, probably because of the higher expression levels of endogenous miR-196b and GATA6 (see Supplementary Figure S2) (Figure 3D). This evidence concerns the gene GATA6 and colonic neoplasm.