AKT1 and colorectal carcinoma: However, unlike in CRC, Rab1A overexpression is not correlated with basal mTORC1 (P-S6K1) or mTORC2 (P-AKT (S473)) signaling in lung cancer cells, and Rab1A knockdown did not significantly alter mTORC1 or mTORC2 activity.