The TANGO2 p.Ser17Ter variant was associated with aggressive disease in both the FHCRC (OR = 2.98, 95% CI 1.46 – 6.08, P = 0.0026) and PLCO (OR = 1.69, 95% CI 1.00 – 2.84; P = 0.048) case-control studies individually (Supplemental Table S7), and had a stronger risk estimate for aggressive disease (OR = 2.06, 95% CI 1.35 – 3.13; P = 0.00075) compared to non-aggressive disease (OR = 1.37, 95% CI 1.00 – 1.89; P = 0.047) in the combined meta-analysis (Table 6). The gene discussed is TANGO2; the disease is aggressive behavior.