CHAD and aggressive behavior: OR5H14 p.Met59Val (OR = 1.43, 95% CI 1.06 – 1.93; P = 0.019) and CHAD p.Ala342Asp (OR = 1.54, 95% CI 1.00 – 2.38; P = 0.049) were associated with non-aggressive disease in the meta-analysis and while the lack of association for the aggressive disease comparison may be due to the small sample size, the risk estimates do not suggest a stronger association with aggressive disease for either the OR5H14 or CHAD variants (OR = 1.23 and 1.65, respectively).