MTOR and neurodegenerative disease: In support of this function, inhibition of mTOR is described to be protective in neurodegenerative diseases such as AD by enhancement of autophagy, a biological process that not only facilitates the clearance of mutant proteins but also significantly reduces the build-up and accumulation of toxic protein aggregates such as NTFs, being caused by Tau-hyperphosphorylation [44, 45].