LC-MS/MS analysis of serum androgens in the patients with PCOS revealedsignificantly increased concentrations of the classic androgen T and itsprecursors A4 and DHEA (all P < 0.001) as well as DHEAS(P = 0.002) when compared with control subjects (Fig. 2). Here, SULT2A1 is linked to polycystic ovary syndrome.