In addition, it has been reported that elevated YAP1 regulates epithelial-mesenchymal transition (EMT) of the atrioventricular cushion [24] and expands multipotent undifferentiated progenitor cells [25], suggesting that YAP1 plays a critical role in promoting cell metastasis, organ growth, cancer stemness and morphological changes. The gene discussed is YAP1; the disease is cancer.