FLT4 and skin basal cell carcinoma: Since YAP1 acts as a critical downstream mediator of VEGF-C/VEGFR3 signaling, we overexpressed YAP1 in BCC cells and found that YAP1 restored anti-VEGFR3 peptide-inhibited SOX2 and OCT4 expression and ALDH activity, as well as migration and invasion abilities (Figure 5c-5e).