Interestingly, albeit no formerly known association with tumor, NPIPB15 I419T point mutation was unanimously detected in three cases (Figure 1c), suggesting its variation could be a common event in Chordoma progression such as IDH1 in glioma [18, 19] and acute myeloid leukemia (AML) [20, 21]. This evidence concerns the gene NPIPB15 and neoplasm.