We found that ERK1 (T202/Y204), ERK2 (T185/Y187) and p38α (T180/Y182) phosphorylation were involved in the dynamic expression of HOXB7 in GC cell lines, while our data indicate that in this context the JNK pathway members, such as JNK1 (T183/Y185), JNK2 (T183/Y185), JNK2 (T221/Y223), are likely not involved. The gene discussed is MAPK3; the disease is gastric cancer.