Up- regulation of PVRIG (poliovirus receptor related immunoglobulin domain containing), LPP (LIM domain containing preferred translocation partner in lipoma), CECR1 (cat eye syndrome chromosome region, candidate 1), Arhgef6 (Rac/Cdc42 guanine nucleotide exchange factor [GEF) 6), IRX3 (iroquois homeobox 3), IGFBP2 (insulin-like growth factor binding protein 2), and CD1d were found. The gene discussed is ADA2; the disease is lipoma.