FOXO3 and neoplasm: As shown in Figure 3, the expression of FoxO1, atrogin-1, MuRF1, Stat3, Socs3 and Gabarap was significantly elevated in the muscle of both L3.6pl flank and orthotopic tumor-bearing groups when compared to sham, while FoxO3, Bnip3 and Acvr2b expression was significantly elevated in only the L3.6pl orthotopic tumor-bearing group.