Here, our findings showed depletion of polyamines induced by SSAT overexpression resulted in decreased cell proliferation in SMMC7721, HepG2 and HCT116 cells which is consisitent with previous reports that SSAT induction plays a key role in cells growth inhibition in glioblastoma cells, Caco-2 colon cancer cells, A2780 human ovarian carcinoma cells [45–47]. This evidence concerns the gene SAT1 and colonic neoplasm.