To explore the role of PIM1 and PIM2 kinases in cancers of the male reproductive organs, we generated conditional PIM1 and PIM2 transgenic mice that overexpress PIM1 and PIM2 in male reproductive organs, which is driven by MMTV-dependent Cre, and analyzed the contribution of these kinases to neoplastic initiation and progression. Here, PIM1 is linked to cancer.