ENAH and neoplasm: Figure 4A shows a tumor cell in direct contact with a macrophage displaying active MENA transcription, and a tumor cell not in contact with a macrophage displaying no active MENA transcription site. The addition of DAPT to the tumor cell-macrophage co-culture prevented the macrophage induction of MENA transcription, even when the tumor cells were in direct contact with macrophages (Fig. 4C).