This isoform splicing pattern of Mena (MenaINV-high/Mena11alow) is associated with directional cell migration towards chemotactic factors such as EGF and HGF, matrix degradation, TMEM assembly and transendothelial migration8, 10, 34, 35, 37, 48, as well as poor outcome in breast cancer patients5, 39, 40. This evidence concerns the gene EGF and breast carcinoma.