RHOA and neoplasm: The co-culture of MDA-MB-231 tumor cells with macrophages resulted in no significant mRNA changes in actin, cortactin, cofilin, N-WASp or the RhoGTPases Rac1, Cdc42, RhoA and RhoC, which all have well defined roles in invadopodia regulation12, 28, 29, 30, 31, 32, 33.