TP53 and early-onset autosomal dominant Alzheimer disease: Table 11 depicts that the interesting border genes extracted from the modules, obtained using THD-Module Extractor, are enriched with KEGG pathways. The KEGG pathways Wnt signaling, Apoptosis, p53 signaling pathway, Notch signaling pathway, Alzheimer’s disease signaling, associated with the interesting border genes and validated using GeneCards and existing literature18, 19, are found to be related to AD. A brief description of the pathways related to AD and the interesting border genes are given in Table 9.