Some of the interesting border genes that are found to be related to AD and validated against the existing literature1, 29 are AATF, APBA2, APBB1, APOD, BACE2, CASP2, CAST, CDK5, CSNK1D, GAP43, HSD17B10, KCNIP3, KLK6, MAPT, NQO1, NRGN, OGT, PADI2, PSEN2, and RCAN1. This evidence concerns the gene CDK5 and Alzheimer disease.