Some of the interesting border genes that are found to be related to AD and validated against the existing literature1, 29 are AATF, APBA2, APBB1, APOD, BACE2, CASP2, CAST, CDK5, CSNK1D, GAP43, HSD17B10, KCNIP3, KLK6, MAPT, NQO1, NRGN, OGT, PADI2, PSEN2, and RCAN1. The gene discussed is CAST; the disease is Alzheimer disease.