Clinical studies indicate that 30% of NSCLC cases have increased Notch1 signaling29 and this activity seems to be critical for driving cancer cell migration and metastasis due to repression of cell adhesion molecules, resulting in loss of cell-to-cell adhesion, protection against hypoxic conditions and promotion of a stem-like signature30. The gene discussed is NOTCH1; the disease is non-small cell lung carcinoma.