These data reinforce the idea that CORT-KO mice are insulin resistant but glucose tolerant in conditions of low/moderate calorie intake, which could be associated to a particular pattern and/or magnitude of GH release in CORT-KO mice that could modify the hepatic glucose production in response to hyperglycemia or to concomitant changes in other regulatory systems such as glucocorticoids42 or ghrelin24, 25, 43, 44, 45 as previously hypothesized13. The gene discussed is INS; the disease is Hyperglycemia.