CORT and obesity due to melanocortin 4 receptor deficiency: Therefore, the present study has been conceived to unveil, for the first time, the putative interplay between SST or CORT and an extreme metabolic situation such as diet-induced obesity in the control of the most relevant pituitary hormonal axes and the whole-body metabolic function by using male and female SST- and CORT-KO mice fed a low-fat or a high-fat diet and, their respective lean and obese littermate controls.