PRL and hydrops fetalis: In addition, PRL levels were significantly reduced in CORT-KO mice (effect of genotype: p < 0.001, two-way ANOVA), being these changes especially marked in HF-diet mice (p < 0.001 and p < 0.05, Bonferroni test in HF-fed females and males, respectively) compared to the gender-matched controls (Fig. 3C).