Kaplan–Meier analysis revealed that patients with higher TMED3 expression had higher recurrence rates (P = 0.0128) and shorter survival times after curative resection (P = 0.0155), indicating that TMED3 expression is associated with HCC progression and may serve as an independent prognostic marker of HCC patient survival. This evidence concerns the gene TMED3 and hepatocellular carcinoma.