Furthermore, multivariate Cox regression analysis indicated that TMED3 expression level, tumor size, presence of HBeAg, and presence of HBsAg were independent risk factors for RFS, and TMED3 expression level, tumor size, tumor number, and presence of HBsAg were independent risk factors for OS in HCC patients (Table 3). Here, TMED3 is linked to hepatocellular carcinoma.