Five autoreactivity targets were found in the age-related maculopathy ancillary (ARMA) study to identify and characterize human macula autoantigens in sera of AMD subjects: two belonging to heat shock protein 70 (HSP70) family HSPA8/9, another heat shock protein HSPB4, also known as alpha-crystallin A chain (CRYAA), Annexin A5, and Protein S100-A9 (Iannaccone et al. 2015). This evidence concerns the gene ANXA5 and age-related macular degeneration.