ELAVL1 and age-related macular degeneration: Samples from AMD patients showed a stronger accumulation of p62/SQSTM1 rather than ELAVL1/HuR, suggesting a greater contribution of autophagy in clearing protein aggregates than proteasome-mediated proteolysis, and in this way, autophagy can be seen as the main mechanism involved in the protein aggregation in RPE cells (Fig. 3b).