IRS2 and Cachexia: Concomitant with lipolysis, local insulin resistance also occurs in cachexia and was reflected in our study by the downregulation of PLIN1, CIDEA, SLC2A4, ADIPOQ, IRS2, and PPARG. Thus, the profound weight loss caused a specific pattern in SAT gene expression, which let us conclude that the post-obese SAT reflects a cachexia-like state rather than healthiness.