CUL4B is encoded on the X Chromosome, and deficiency in males is associated with intellectual disability, seizures, aggressive outbursts, central obesity, muscle wasting, short stature, macrocephaly, and dysmorphic features including brachydactyly, macroglossia, pes cavus, and prominent upper lip (Tarpey et al. 2007; Zhao and Sun 2012). The gene discussed is CUL4B; the disease is Intellectual disability.