SCN8A and Intellectual disability: Several studies have associated mutations in SCN8A with epilepsy, intellectual disability, and cranial features such as microcephaly (Veeramah et al. 2012; de Kovel et al. 2014; Estacion et al. 2014; Ohba et al. 2014; Vaher et al. 2014; Blanchard et al. 2015; Larsen et al. 2015; Wagnon and Meisler 2015).