We surveyed variants in potential hereditary loci including those in TP53 (causative gene for Li–Fraumeni syndrome), BRCA2 (causative gene for hereditary breast/ovarian cancer), and mismatch repair genes (MSH2, MSH6, PMS2, and EPCAM, i.e., causative genes for Lynch syndrome), but found only common SNPs. The gene discussed is MSH2; the disease is Lynch syndrome.