While a previous report of two pediatric cohorts representing children with CKD (CKiD) and nephrotic syndrome (Nephrotic Syndrome Study Network; NEPTUNE) showed similar APOL1 characteristics in terms of FSGS diagnosis and disease progression (15), the association of APOL1 and cardiovascular comorbidities in the presence of CKD has not been explored. This evidence concerns the gene APOL1 and focal segmental glomerulosclerosis.