Ito et al. (6) using data from the Jackson Heart Study (JHS) and Women’s Health Initiative (WHI) demonstrated that the APOL1 kidney risk alleles confer a twofold risk of cardiovascular events, without significant changes in left ventricular mass, whereas the Systolic Blood Pressure Intervention Trial (SPRINT) showed the absence of an APOL1 association with prevalent cardiovascular disease in a non-diabetic adult sample (26). Here, APOL1 is linked to cardiovascular disorder.