Although the source of circulating 2-AG has not yet been documented, a possible mechanism underlying its elevated levels in PWS may lie in the upregulated activity of its bio-synthesizing enzymes, diacylglycerol lipase alpha and beta [3], and not an increased ingestion of a fatty diet since these PWS subjects are normally maintained on a healthy calorie-restricted diet to prevent weight gain. This evidence concerns the gene DAGLA and Prader-Willi syndrome.