Among the different gene mutations involved in PWS that have been engineered into mice (such as SNORD116/MBII-85, makorin-3 (Mkrn3), and necdin (Ndn) [27]), only Magel2-null mice recapitulate some of the metabolic and hormonal aspects of humans with PWS [22], [24], [28]. Here, MKRN3 is linked to Prader-Willi syndrome.