CNR1 and obesity due to melanocortin 4 receptor deficiency: A role for peripheral eCBs in regulating appetite and body weight is indicated by the increased peripheral eCB ‘tone’ in diet-induced obesity (DIO), manifested by increased expression of CB1R in peripheral tissues [13], [14], [15], [16], [17] and/or elevated levels of AEA and 2-AG [18], [19].