Conversely, liver-specific knockout of the phosphatase and tensin homolog (PTEN), which is a phosphatidylinositol-3,4,5-triphosphate (PIP3) phosphatase that serves to antagonize insulin’s metabolic actions, produces macrovesicular steatosis, NASH (including Mallory-Denk bodies), fibrosis, and HCC (69). The gene discussed is INS; the disease is hepatocellular carcinoma.