In conclusion, our model-based study implicates the IN population as a significant and vital constituent of the retino-geniculo-cortical pathway, regulating the state transitions of both TCR and TRN populations, and maintaining an overall homeostatic balance in the LGN circuitry in a normal awake state; any direct or indirect disruption to its synaptic mechanisms may cause unwanted brain rhythms that are EEG and LFP markers of neuro-psychiatric disorders. Here, TNPO1 is linked to psychiatric disorder.