In addition to specific actions that relate to the tumor cell’s response to oxygen availability, HIF-1 interacts with the PI3K/AKT signaling path to act as a regulator of cancer metabolism, proliferation and glycolysis (Pore et al., 2006; Wei et al., 2013; Courtnay et al., 2015; Justus et al., 2015). The gene discussed is AKT1; the disease is cancer.