For example, targeting PKCα-mediated signal transduction pathway induces cell killing in AML cells by inhibiting Bcl-2 phosphorylation and blocking ERK activation.30 Herein, we showed that forced expression of miR-150 significantly repressed endogenous expression of PKCα, and luciferase reporter/mutagenesis assays confirmed that PRKCA is a transcriptional target of miR-150. This evidence concerns the gene PRKCA and acute myeloid leukemia.