They are implicated in small-molecule metabolic process (POM121, PISD, STX1A, AMD1, PRKCA, NDST1, and ACSL4), transcriptional regulation (FOXO4, IKZF1, TET3, NFIC, RUNX1, EIF4B, and CTIF), RNA metabolic process (EIF4B, PRKCA, and PDCD4), proteoglycan synthesis in cancer (PDCD4, PRKCA, FZD4, and EIF4B), mTOR signaling pathway (PRKCA and EIF4B), and Wnt signaling pathway (FZD4 and PRKCA). The gene discussed is PISD; the disease is cancer.