The repression of miR-150 maturation by MLL-fusion genes accelerated leukemogenesis in an MLL/AF9 murine model and miR-150 expression in this model inhibited leukemia cell growth through targeting MYB and FLT3.12 The critical tumor suppressor role of miR-150 in MLL-rearranged AML was further confirmed by a subsequent, independent study, in which CBL and EGR2 were also identified as bona fide targets of miR-150.13 These data suggest that miR-150 acts as a tumor suppressor in certain leukemias and might have therapeutic potentials in treating leukemia. This evidence concerns the gene CBL and leukemia.