SMO and breast cancer: More interestingly, 12 resulted active on the D473H drug-resistant Smo mutant, the main cause of failure of the Vismodegib treatment, suggesting the possible therapeutic applicability of 12 for the treatment of Vismodegib-resistant tumors.75 The strong effect of 12 to inhibit Hh activity compared with BC displacement assay supposed its ability to affect other positive regulators of the Hh signaling.