NF-κB phosphorylation has an important role in transcriptions of snail and twist.43 Combined with the result that 4-en-3-one treatment for 24 h suppressed NF-κB phosphorylation, it was likely that the inhibitory effect of 4-en-3-one on ADC cells migration was partly due to block caveolin-1/Akt/NF-κB-signaling pathway. This evidence concerns the gene AKT1 and AIDS dementia complex.