IL6 and coronary artery disorder: These findings would be consistent with the suggestions from previous studiesthat, in addition to established risk factors such as cholesterol7 and BP,6 circulating inflammatory markers,9 and VitD23 showed strong associations with outdoor temperature and may contribute toincreased incidence of CVD in winter.1 The association of temperature with SBP, LDL-cholesterol and IL-6 levelsmay be particularly relevant, as previous trials and Mendelian randomization(MR) studies support their causal role in CHD risk.4,5,24