Theinflammatory hypothesis of CVD is currently being formally tested in randomizedcontrolled trials (RCTs).24 To date, MR studies for IL-6 suggested a causal role in CHD, in contrastto null associations in MR studies for CRP and fibrinogen.8 Therefore, the findings on IL-6 are particularly important: in this studya decrease of about 10°C in temperatures (difference between the coldest andwarmest month, January–August) would be associated with an increase of0.06 pg/ml in IL-6 levels. The gene discussed is CRP; the disease is coronary artery disorder.