Our network analyses using 2 different bioinformatics tools also revealed a central role for MMP9 in AAA, with IPA identifying direct interactions between ERG, IL6R and LDLR, and MMP9, and Consensus PathDB identifying a direct interaction between ERG and MMP9 with secondary interactions between both SMYD2 and LDLR and MMP9. The gene discussed is SMYD2; the disease is triple-A syndrome.