PLTP and triple-A syndrome: Closer to the strongest association signal are ZNF335 and PCIF1. There is no literature evidence for any potential link for ZNF335 to AAA and the only identified genetic association of ZNF335 is with celiac disease.42 Although rs181914932 is upstream and more proximal to PCIF1, it has been associated with the activity of PLTP,43 an adjacent gene in the same locus.