Gene set descriptions included multiple functional classes relevant to vascular biology, ie, transforming growth factor-β regulation, lipoprotein metabolism, inflammation-induced extracellular matrix remodeling (regulatory factor X1), vascular smooth muscle cell function, vascular injury including hemorrhage, immune cell function (particularly T and B cells), acute phase response including IL6 secretion, apoptosis, hyperglycemia and the phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha, c-Jun N-terminal kinase, and mitogen-activated kinase-like protein cascades. The gene discussed is RFX1; the disease is Hyperglycemia.