However, at multivariate analyses including all three study groups and adjusted for age, year of diagnosis, tumor stage at diagnosis and ER and PgR status, only BRCA-wild type status was related to a statistically significant improvement in overall compared to the sporadic breast cancer group (HR = 0,51; 95% CI 0,28-0,93; p=0.028). This evidence concerns the gene ESR1 and neoplasm.