PTH1R and primary failure of tooth eruption: While the first reported 3 mutations (c.463G>T, c.543+1G>A, c.1050-3C>G) in patients with PFE were predicted to generate loss-of-function proteins [3], the spectrum of PTH1R mutations by now has been expanded by several investigators showing the occurrence of more than 40 potentially pathogenic mutations [4, 6–8].