Besides, we found in this cluster an up-regulation of genes of natriuretic peptides ANP and BNP, currently used as biomarkers of heart disease.[23] Meirovich et al have already reported that BNP plasma levels were increased during a cardiac ACR episode grade 3A[24], promoted by pro-inflammatory and other cytokines including CCL5. The gene discussed is NPPB; the disease is heart disorder.