Among them, 37 genes have differential expression signals (P value < 0.05) in synovial tissues or PBMCs of RA patients of Asian and European, and,11 genes (ABCF1, FLOT1, HLA-F, IER3, TUBB, ZKSCAN4,BTN3A3, HSP90AB1, BRD2, HLA-G and HLA-DMA) are highly verified in three or four functional studies. This evidence concerns the gene ZKSCAN4 and rheumatoid arthritis.