PPM1K and type 2 diabetes mellitus: At the PPM1K locus, both the lead SNPs in the BCAA association analyses, rs1440581 (r2 = 0.88) and rs7678928 (r2 = 0.70), were in linkage disequilibrium with the lead type 2 diabetes SNP at the locus, rs1975393 (Fig 3B).