TFRC and cancer: Interestingly, recent work has also shown that the expression of TfR is a poor prognostic indicator in GBM, and that dysregulated iron metabolism including increased TfR expression and ferritin expression is associated with cancer stem cells in GBM [36] This suggests that the gene signature identified here is, at least in part, sorting cancers with more robust stem cell populations from cancers with fewer cancer stem cells.